InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Commd1

Summary

InnateDB Protein

IDBP-536216.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Commd1

Protein Name

COMM domain containing 1

Synonyms

AI256843; Murr1; U2/Mu;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124719

InnateDB Gene

IDBG-154032 (Commd1)

Protein Structure

UniProt Annotation

Function

Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding

Biological Process

GO:0006878	cellular copper ion homeostasis
GO:0031398	positive regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0055070	copper ion homeostasis