InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Herpud1

Summary

InnateDB Protein

IDBP-536258.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Herpud1

Protein Name

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Synonyms

Herp; Mifl; SUP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124201

InnateDB Gene

IDBG-182026 (Herpud1)

Protein Structure

UniProt Annotation

Function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0006986	response to unfolded protein
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031396	regulation of protein ubiquitination
GO:0032092	positive regulation of protein binding
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process