Version 5.4
Mus musculus Protein: Agpat5
Summary
InnateDB Protein IDBP-536317.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agpat5
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
Synonyms 1110013A05Rik; D8Ertd319e;
Species Mus musculus
Ensembl Protein ENSMUSP00000117025
InnateDB Gene IDBG-137452 (Agpat5)
Protein Structure
UniProt Annotation
Function Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable. {ECO:0000269PubMed:15367102}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15367102}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006639 acylglycerol metabolic process
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1196345
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D1E8
PhosphoSite PhosphoSite-Q9D1E8
TrEMBL F8WGD9
UniProt Splice Variant
Entrez Gene 52123
UniGene Mm.468431
RefSeq NP_081068
MGI ID
MGI Symbol Agpat5
OMIM
CCDS CCDS22126
HPRD
IMGT
EMBL AC129567 AK003649 AK082137 AK089885 AK152709 AK152889 AK155378 AY161042 BC031987
GenPept AAH31987 AAN75571 BAB22915 BAC38421 BAC40983 BAE31436 BAE31572 BAE33229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca