InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nhej1

Summary

InnateDB Protein

IDBP-536323.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nhej1

Protein Name

nonhomologous end-joining factor 1

Synonyms

1700029B21Rik; cernunnos; XLF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116797

InnateDB Gene

IDBG-169106 (Nhej1)

Protein Structure

UniProt Annotation

Function

DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. {ECO:0000269PubMed:17360556}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0010212	response to ionizing radiation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation