Version 5.4
Mus musculus Protein: Rapgef1
Summary
InnateDB Protein IDBP-536327.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rapgef1
Protein Name Rap guanine nucleotide exchange factor (GEF) 1
Synonyms 4932418O06Rik; C3G; Grf2;
Species Mus musculus
Ensembl Protein ENSMUSP00000121615
InnateDB Gene IDBG-153837 (Rapgef1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0001568 blood vessel development
GO:0009967 positive regulation of signal transduction
GO:0016337 single organismal cell-cell adhesion
GO:0043087 regulation of GTPase activity
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0051898 negative regulation of protein kinase B signaling
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
Protein Structure and Domains
PDB ID MGI:104580
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CXV1
UniProt Splice Variant
Entrez Gene 107746
UniGene Mm.298274
RefSeq
MGI ID
MGI Symbol Rapgef1
OMIM
CCDS
HPRD
IMGT
EMBL AL845323
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca