InnateDB Protein
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IDBP-536369.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Derl2
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Protein Name
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Der1-like domain family, member 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000117052
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InnateDB Gene
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IDBG-195837 (Derl2)
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Protein Structure
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Function |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with lowest levels in brain and heart. {ECO:0000269PubMed:11500051, ECO:0000269PubMed:16186509}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
GO:0001967
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suckling behavior
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GO:0008284
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positive regulation of cell proliferation
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GO:0030307
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positive regulation of cell growth
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GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0030970
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retrograde protein transport, ER to cytosol
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Cellular Component |
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PDB ID |
MGI:2151483
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InterPro |
IPR007599
Derlin
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PFAM |
PF04511
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BNI4
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PhosphoSite |
PhosphoSite-Q8BNI4
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TrEMBL |
Q3U957
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UniProt Splice Variant |
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Entrez Gene |
116891
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UniGene |
Mm.470408
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RefSeq |
NP_291040
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MGI ID |
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MGI Symbol |
Derl2
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OMIM |
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CCDS |
CCDS24972
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HPRD |
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IMGT |
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EMBL |
AF208064
AK048627
AK077659
AK082564
AK083632
AK151934
AL596136
BC005682
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GenPept |
AAH05682
AAL14868
BAC33399
BAC36934
BAC38533
BAC38974
BAE30810
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