Version 5.4
Mus musculus Protein: Stau2
Summary
InnateDB Protein IDBP-536392.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stau2
Protein Name staufen (RNA binding protein) homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124303
InnateDB Gene IDBG-135149 (Stau2)
Protein Structure
UniProt Annotation
Function RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15166236}. Nucleus {ECO:0000269PubMed:15166236}. Nucleus, nucleolus {ECO:0000269PubMed:15166236}. Endoplasmic reticulum {ECO:0000269PubMed:15166236}. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. May also be found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.
Disease Associations
Tissue Specificity Expressed in brain and neurons, where isoform 2 and isoform 3 appear to be the most abundant. Expressed at the neuromuscular junction of the extensor digitorum longus, tibialis anterior and soleus muscles. Expression at neuromuscular junctions is most pronounced in slow-twitch muscle. Also weakly expressed in heart, kidney, ovary and testis. {ECO:0000269PubMed:12140260, ECO:0000269PubMed:12859680}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:1352508
InterPro IPR014720 Double-stranded RNA-binding domain
PFAM PF00035
PRINTS
PIRSF
SMART SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CJ67
PhosphoSite PhosphoSite-Q8CJ67
TrEMBL E2QRQ3
UniProt Splice Variant
Entrez Gene 29819
UniGene Mm.401175
RefSeq
MGI ID 1UHZ
MGI Symbol Stau2
OMIM
CCDS
HPRD
IMGT
EMBL AC115952 AC116695 AC162448 AC167117 AF459099 AF459100 AK015087 AK028390 BC010300 BC025118
GenPept AAH10300 AAH25118 AAN37928 AAN37929 BAB29708 BAC25926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca