Version 5.4
Mus musculus Protein: Eif5a
Summary
InnateDB Protein IDBP-536624.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif5a
Protein Name eukaryotic translation initiation factor 5A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000123402
InnateDB Gene IDBG-264162 (Eif5a)
Protein Structure
UniProt Annotation
Function mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17707773}. Nucleus {ECO:0000269PubMed:17707773}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=The N-terminal extension contributes in signaling this protein to nuclear localization.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0043022 ribosome binding
Biological Process
GO:0006452 translational frameshifting
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0045901 positive regulation of translational elongation
GO:0045905 positive regulation of translational termination
Cellular Component
Protein Structure and Domains
PDB ID MGI:106248
InterPro IPR001884 Translation elongation factor IF5A
IPR005824 KOW
IPR008991 Translation protein SH3-like domain
IPR012340 Nucleic acid-binding, OB-fold
IPR020189 Translation elongation factor, IF5A C-terminal
PFAM PF00467
PF01287
PRINTS
PIRSF PIRSF003025
SMART SM00739
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P63242
TrEMBL
UniProt Splice Variant
Entrez Gene 276770
UniGene
RefSeq
MGI ID
MGI Symbol Eif5a
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca