InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KALRN

Summary

InnateDB Protein

IDBP-53665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KALRN

Protein Name

kalirin, RhoGEF kinase

Synonyms

ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP; TRAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000240874

InnateDB Gene

IDBG-53661 (KALRN)

Protein Structure

UniProt Annotation

Function

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. {ECO:0000269PubMed:10023074}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10023074}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10023074}. Note=Associated with the cytoskeleton.

Disease Associations

Coronary heart disease 5 (CHDS5) [MIM:608901]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269PubMed:17357071}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. {ECO:0000269PubMed:10023074}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0016192	vesicle-mediated transport
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001251 CRAL-TRIO domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR018159 Spectrin/alpha-actinin

PFAM

PF00621
PF00650
PF13716
PF00169
PF00435

PRINTS

PIRSF

SMART

SM00325
SM00516
SM00233
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60229