InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KALRN

Summary

InnateDB Gene

IDBG-53661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KALRN

Gene Name

kalirin, RhoGEF kinase

Synonyms

ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP; TRAD

Species

Homo sapiens

Ensembl Gene

ENSG00000160145

Encoded Proteins

IDBP-53663

kalirin, RhoGEF kinase

IDBP-53665

kalirin, RhoGEF kinase

IDBP-53667

kalirin, RhoGEF kinase

IDBP-53669

kalirin, RhoGEF kinase

IDBP-243479

kalirin, RhoGEF kinase

IDBP-383310

kalirin, RhoGEF kinase

IDBP-383330

kalirin, RhoGEF kinase

IDBP-383339

kalirin, RhoGEF kinase

IDBP-481352

kalirin, RhoGEF kinase

IDBP-479424

kalirin, RhoGEF kinase

IDBP-484402

kalirin, RhoGEF kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Huntington\'s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:124080023-124726325

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000360013	ENSP00000353109
ENST00000240874	ENSP00000240874
ENST00000291478	ENSP00000291478
ENST00000354186	ENSP00000346122
ENST00000393501
ENST00000393496	ENSP00000377134
ENST00000448253	ENSP00000395236
ENST00000439170	ENSP00000402950
ENST00000454902	ENSP00000400064
ENST00000477496
ENST00000488825
ENST00000460856	ENSP00000418611
ENST00000483658
ENST00000498499
ENST00000522553
ENST00000484224
ENST00000494648
ENST00000473056
ENST00000471431
ENST00000459915	ENSP00000420318
ENST00000484542
ENST00000462213	ENSP00000418790

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0016192	vesicle-mediated transport
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway