InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgir

Summary

InnateDB Protein

IDBP-536675.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgir

Protein Name

prostaglandin I receptor (IP)

Synonyms

IP; PGI2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122080

InnateDB Gene

IDBG-147219 (Ptgir)

Protein Structure

UniProt Annotation

Function

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0048662	negative regulation of smooth muscle cell proliferation

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99535

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000370 Prostacyclin (prostanoid IP) receptor
IPR001105 Thromboxane receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10328

PRINTS

PR00237
PR00856
PR00429
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43252