Version 5.4
Mus musculus Gene: Ptgir
Summary
InnateDB Gene IDBG-147219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptgir
Gene Name prostaglandin I receptor (IP)
Synonyms IP; PGI2
Species Mus musculus
Ensembl Gene ENSMUSG00000043017
Encoded Proteins
IDBP-147221
prostaglandin I receptor (IP)
IDBP-536675
prostaglandin I receptor (IP)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160013:
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16906490-16910905
Strand Forward strand
Band A2
Transcripts
ENSMUST00000086101 ENSMUSP00000083270
ENSMUST00000144408 ENSMUSP00000122080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032496 response to lipopolysaccharide
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0048662 negative regulation of smooth muscle cell proliferation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160013
View Gene Order
ENSBTAG00000014585
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_230556
Prostanoid ligand receptors pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_262579
Prostacyclin signalling through prostacyclin receptor pathway
REACT_231468
GPCR ligand binding pathway
REACT_188257
Signal Transduction pathway
REACT_253164
Eicosanoid ligand-binding receptors pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_18425
Prostanoid ligand receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_604
Hemostasis pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
Cross-References
SwissProt P43252
TrEMBL E9PY53 Q3U4F1 Q7TSX3
UniProt Splice Variant
Entrez Gene 19222
UniGene Mm.287572 Mm.484094
RefSeq NM_008967 XM_006539670
OMIM
CCDS CCDS20857
HPRD
IMGT
MGI ID MGI:99535
MGI Symbol Ptgir
EMBL AC148981 AK154272 AY285778 BC094386 CH466654 D26157
GenPept AAH94386 AAP37444 BAA05144 BAE32480 EDL42070
RNA Seq Atlas 19222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca