InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KALRN

Summary

InnateDB Protein

IDBP-53669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KALRN

Protein Name

kalirin, RhoGEF kinase

Synonyms

ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP; TRAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000346122

InnateDB Gene

IDBG-53661 (KALRN)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001251 CRAL-TRIO domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR018159 Spectrin/alpha-actinin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM