InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Anxa2

Summary

InnateDB Protein

IDBP-536726.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anxa2

Protein Name

annexin A2

Synonyms

AW215814; Cal1h;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117979

InnateDB Gene

IDBG-181662 (Anxa2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008092	cytoskeletal protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0001525	angiogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0007589	body fluid secretion
GO:0030199	collagen fibril organization
GO:0031340	positive regulation of vesicle fusion
GO:0042730	fibrinolysis
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0048146	positive regulation of fibroblast proliferation
GO:0051099	positive regulation of binding
GO:0071229	cellular response to acid
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005811	lipid particle
GO:0005938	cell cortex
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0044354	macropinosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88246

InterPro

IPR001464 Annexin
IPR002389 Annexin, type II
IPR018502 Annexin repeat

PFAM

PF00191

PRINTS

PR00196
PR00198

PIRSF

SMART

SM00335

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B0V2N8

UniProt Splice Variant

Entrez Gene

12306

UniGene

Mm.238343

RefSeq

MGI ID

MGI Symbol

Anxa2

OMIM

CCDS

HPRD

IMGT

EMBL

CT009708

GenPept