InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Anxa2

Summary

InnateDB Gene

IDBG-181662.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anxa2

Gene Name

annexin A2

Synonyms

AW215814; Cal1h

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032231

Encoded Proteins

IDBP-181664

annexin A2

IDBP-538491

annexin A2

IDBP-536726

annexin A2

IDBP-538828

annexin A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21115493

Anxa2 :: S100a10 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce serine phosphorylation of Anxa2 and prevents the translocation to cell surface.

InnateDB Annotation from Orthologs

Summary

PMID 19965653

[Homo sapiens] ANXA2 is found in a heterotetrameric complex with S100A10, serving as a key extracellular binding partner for pathogens and host proteins alike and can also can be shed or secreted. ANXA2 tetramer can activate human and murine macrophages through TLR4 demonstrating an important role for ANXA2 in the detection of danger to the host, whether from injury or invasion.

PMID 21115493

[Homo sapiens] ANXA2 :: S100A10 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce serine phosphorylation of ANXA2 and prevents the translocation to cell surface.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182718:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:69453620-69491795

Strand

Forward strand

Band

Transcripts

ENSMUST00000034756	ENSMUSP00000034756
ENSMUST00000123470	ENSMUSP00000122175
ENSMUST00000134907	ENSMUSP00000117979
ENSMUST00000143878
ENSMUST00000136282	ENSMUSP00000117855
ENSMUST00000154591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008092	cytoskeletal protein binding
GO:0017137	Rab GTPase binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0044548	S100 protein binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001765	membrane raft assembly
GO:0001934	positive regulation of protein phosphorylation
GO:0006900	membrane budding
GO:0007589	body fluid secretion
GO:0030199	collagen fibril organization
GO:0031340	positive regulation of vesicle fusion
GO:0036035	osteoclast development
GO:0042730	fibrinolysis
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0048146	positive regulation of fibroblast proliferation
GO:0051099	positive regulation of binding
GO:0051290	protein heterotetramerization
GO:0071229	cellular response to acid
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0001726	ruffle
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0031982	vesicle
GO:0035749	myelin sheath adaxonal region
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0044354	macropinosome
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome