InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema6a

Summary

InnateDB Protein

IDBP-536821.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema6a

Protein Name

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

Synonyms

9330158E07; A730020P05Rik; AI851735; b2b997Clo; Sema6A-1; Semaq; VIa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121442

InnateDB Gene

IDBG-145724 (Sema6a)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000269PubMed:16205717, ECO:0000269PubMed:19063725, ECO:0000269PubMed:20877282, ECO:0000269PubMed:20881961}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269PubMed:20881961}.

Disease Associations

Tissue Specificity

Particularly high levels in spinal cord, cerebellum, metencephalon, superior and inferior colliculus, diencephalon, olfactory bulb and eye. {ECO:0000269PubMed:16205717}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001764	neuron migration
GO:0006915	apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0051642	centrosome localization
GO:0071526	semaphorin-plexin signaling pathway
GO:2001224	positive regulation of neuron migration