InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDH1

Summary

InnateDB Protein

IDBP-53688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDH1

Protein Name

malate dehydrogenase 1, NAD (soluble)

Synonyms

HEL-S-32; MDH-s; MDHA; MGC:1375; MOR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000233114

InnateDB Gene

IDBG-53686 (MDH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	22 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004470	malic enzyme activity
GO:0016491	oxidoreductase activity
GO:0016615	malate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060	L-malate dehydrogenase activity
GO:0047860	diiodophenylpyruvate reductase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006099	tricarboxylic acid cycle
GO:0006108	malate metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001236 Lactate/malate dehydrogenase, N-terminal
IPR001557 L-lactate/malate dehydrogenase
IPR010945 Malate dehydrogenase, type 2
IPR011274 Malate dehydrogenase, NAD-dependent, cytosolic
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR022383 Lactate/malate dehydrogenase, C-terminal

PFAM

PF00056
PF02866

PRINTS

PR00086

PIRSF

PIRSF000102

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt