Version 5.4
Homo sapiens Gene: MDH1
Summary
InnateDB Gene IDBG-53686.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDH1
Gene Name malate dehydrogenase 1, NAD (soluble)
Synonyms HEL-S-32; MDH-s; MDHA; MGC:1375; MOR2
Species Homo sapiens
Ensembl Gene ENSG00000014641
Encoded Proteins
IDBP-53688
malate dehydrogenase 1, NAD (soluble)
IDBP-293025
malate dehydrogenase 1, NAD (soluble)
IDBP-293034
malate dehydrogenase 1, NAD (soluble)
IDBP-377683
malate dehydrogenase 1, NAD (soluble)
IDBP-377685
malate dehydrogenase 1, NAD (soluble)
IDBP-377689
malate dehydrogenase 1, NAD (soluble)
IDBP-377690
malate dehydrogenase 1, NAD (soluble)
IDBP-377694
malate dehydrogenase 1, NAD (soluble)
IDBP-601400
malate dehydrogenase 1, NAD (soluble)
IDBP-602576
malate dehydrogenase 1, NAD (soluble)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:63588609-63607197
Strand Forward strand
Band p15
Transcripts
ENST00000233114 ENSP00000233114
ENST00000409908 ENSP00000386743
ENST00000409476 ENSP00000386719
ENST00000442225 ENSP00000399004
ENST00000436321 ENSP00000394504
ENST00000454035 ENSP00000409027
ENST00000432309 ENSP00000410073
ENST00000421012 ENSP00000400937
ENST00000485781
ENST00000485155
ENST00000462944
ENST00000472098
ENST00000484538
ENST00000495083
ENST00000539945 ENSP00000438144
ENST00000544381 ENSP00000446395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 22 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004470 malic enzyme activity
GO:0016491 oxidoreductase activity
GO:0016615 malate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase activity
GO:0047860 diiodophenylpyruvate reductase activity
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006099 tricarboxylic acid cycle
GO:0006107 oxaloacetate metabolic process
GO:0006108 malate metabolic process
GO:0006734 NADH metabolic process
GO:0019674 NAD metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020321
View Gene Order
ENSBTAG00000019295
Not yet available
Pathways
NETPATH
REACTOME
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00620
Pyruvate metabolism pathway
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001199111 NM_001199112 NM_005917 XM_005264320
HUGO
OMIM
CCDS CCDS1874 CCDS56121 CCDS56122
HPRD 01100
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca