InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fxyd5

Summary

InnateDB Protein

IDBP-536883.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fxyd5

Protein Name

FXYD domain-containing ion transport regulator 5

Synonyms

EF-8; Oit2; RIC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125398

InnateDB Gene

IDBG-171987 (Fxyd5)

Protein Structure

UniProt Annotation

Function

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Spleen, lung, skeletal muscle, and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005216	ion channel activity
GO:0045296	cadherin binding

Biological Process

GO:0006811	ion transport
GO:0034220	ion transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1201785

InterPro

IPR000272 Ion-transport regulator, FXYD motif

PFAM

PF02038

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97808

PhosphoSite

PhosphoSite-P97808

TrEMBL

Q3TDW1

UniProt Splice Variant

Entrez Gene

18301

UniGene

Mm.488048

RefSeq

NP_001104543

MGI ID

MGI Symbol

Fxyd5

OMIM

CCDS

CCDS21121

HPRD

IMGT

EMBL

AK003068 AK155763 AK169966 AK170810 CH466593 U72680

GenPept

AAB51040 BAB22545 BAE33425 BAE41487 BAE42043 EDL23968