Version 5.4
| Mus musculus Gene: Fxyd5 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-171987.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Fxyd5 | ||||||||
| Gene Name | FXYD domain-containing ion transport regulator 5 | ||||||||
| Synonyms | EF-8; Oit2; RIC | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000009687 | ||||||||
| Encoded Proteins |
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
FXYD domain-containing ion transport regulator 5
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial cadherin, a calcium-dependent adhesion protein and is associated with cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 7:31032722-31042481 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | B1 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Mm.488048 | ||||||||
| RefSeq | NM_001111073 NM_001287213 NM_001287217 NM_008761 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS21121 CCDS71935 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | |||||||||
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| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||