Version 5.4
Mus musculus Protein: Hspd1
Summary
InnateDB Protein IDBP-536896.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hspd1
Protein Name heat shock protein 1 (chaperonin)
Synonyms 60kDa; Hsp60;
Species Mus musculus
Ensembl Protein ENSMUSP00000119336
InnateDB Gene IDBG-155162 (Hspd1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0002039 p53 binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0051087 chaperone binding
Biological Process
GO:0002368 B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 response to unfolded protein
GO:0032727 positive regulation of interferon-alpha production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0042026 protein refolding
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0043032 positive regulation of macrophage activation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0048291 isotype switching to IgG isotypes
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0009986 cell surface
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135 coated vesicle
GO:0030141 secretory granule
GO:0043231 intracellular membrane-bounded organelle
GO:0046696 lipopolysaccharide receptor complex
Protein Structure and Domains
PDB ID MGI:96242
InterPro IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
PFAM PF00118
PRINTS PR00298
PR00304
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z7J9
UniProt Splice Variant
Entrez Gene 15510
UniGene Mm.486509
RefSeq
MGI ID
MGI Symbol Hspd1
OMIM
CCDS
HPRD
IMGT
EMBL AC108391
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca