InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpar1

Summary

InnateDB Protein

IDBP-537016.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpar1

Protein Name

lysophosphatidic acid receptor 1

Synonyms

AI326300; Edg2; Gpcr26; Kdt2; lpA1; vzg-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116856

InnateDB Gene

IDBG-150490 (Lpar1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0005543	phospholipid binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010977	negative regulation of neuron projection development
GO:0032060	bleb assembly
GO:0035025	positive regulation of Rho protein signal transduction
GO:0042552	myelination
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060999	positive regulation of dendritic spine development
GO:0071453	cellular response to oxygen levels
GO:0071673	positive regulation of smooth muscle cell chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0043198	dendritic shaft

Protein Structure and Domains

PDB ID

MGI:108429

InterPro

IPR002277 Lysophosphatidic acid receptor EDG-2

PFAM

PRINTS

PR01148

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2AMJ1

UniProt Splice Variant

Entrez Gene

14745

UniGene

Mm.4772

RefSeq

MGI ID

MGI Symbol

Lpar1

OMIM

CCDS

HPRD

IMGT

EMBL

AL807748 AL929390

GenPept