InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdcd10

Summary

InnateDB Protein

IDBP-537082.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdcd10

Protein Name

programmed cell death 10

Synonyms

2410003B13Rik; Ccm3; Tfa15; Tfar15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125752

InnateDB Gene

IDBG-152450 (Pdcd10)

Protein Structure

UniProt Annotation

Function

Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. {ECO:0000250, ECO:0000269PubMed:20371769}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000269PubMed:20371769}; Peripheral membrane protein {ECO:0000269PubMed:20371769}; Cytoplasmic side {ECO:0000269PubMed:20371769}. Note=Partially colocalizes with endogenous PXN at the leading edges of migrating cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity