Version 5.4
Mus musculus Gene: Pdcd10
Summary
InnateDB Gene IDBG-152450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdcd10
Gene Name programmed cell death 10
Synonyms 2410003B13Rik; Ccm3; Tfa15; Tfar15
Species Mus musculus
Ensembl Gene ENSMUSG00000027835
Encoded Proteins
IDBP-152452
programmed cell death 10
IDBP-537082
programmed cell death 10
IDBP-536888
programmed cell death 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114209:
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:75516490-75556856
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000029424 ENSMUSP00000029424
ENSMUST00000161137 ENSMUSP00000125752
ENSMUST00000159519
ENSMUST00000160196
ENSMUST00000162138 ENSMUSP00000124421
ENSMUST00000159217
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0008284 positive regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114209
View Gene Order
ENSBTAG00000031709
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL E0CY82
UniProt Splice Variant
Entrez Gene 56426
UniGene Mm.316473 Mm.389387 Mm.402373
RefSeq NM_019745
OMIM
CCDS CCDS17414
HPRD
IMGT
MGI ID MGI:1928396
MGI Symbol Pdcd10
EMBL AC140430 AC168120
GenPept
RNA Seq Atlas 56426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca