Version 5.4
Mus musculus Protein: Cul4a
Summary
InnateDB Protein IDBP-537280.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cul4a
Protein Name cullin 4A
Synonyms 2810470J21Rik; AW495282;
Species Mus musculus
Ensembl Protein ENSMUSP00000123074
InnateDB Gene IDBG-134595 (Cul4a)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 230 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 230 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008284 positive regulation of cell proliferation
GO:0030097 hemopoiesis
GO:0030853 negative regulation of granulocyte differentiation
GO:0035019 somatic stem cell maintenance
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0051246 regulation of protein metabolic process
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 regulation of DNA damage checkpoint
GO:2000819 regulation of nucleotide-excision repair
Cellular Component
GO:0031461 cullin-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1914487
InterPro IPR001373 Cullin, N-terminal
IPR016159 Cullin repeat-like-containing domain
PFAM PF00888
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6UV36
UniProt Splice Variant
Entrez Gene 99375
UniGene
RefSeq
MGI ID
MGI Symbol Cul4a
OMIM
CCDS
HPRD
IMGT
EMBL AC133520
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca