Version 5.4
Mus musculus Protein: Wdr83
Summary
InnateDB Protein IDBP-537309.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr83
Protein Name WD repeat domain containing 83
Synonyms 1500041N16Rik; Morg1;
Species Mus musculus
Ensembl Protein ENSMUSP00000121568
InnateDB Gene IDBG-176692 (Wdr83)
Protein Structure
UniProt Annotation
Function Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269PubMed:15118098}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:15118098}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0006397 mRNA processing
Cellular Component
GO:0005737 cytoplasm
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1915086
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAJ4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 67836
UniGene Mm.334680
RefSeq
MGI ID
MGI Symbol Wdr83
OMIM
CCDS
HPRD
IMGT
EMBL AK005790 AK020654 AY365434 BC005587 BC019369 BC094624
GenPept AAH05587 AAH19369 AAH94624 AAQ64635 BAB24241 BAB32164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca