InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Socs6

Summary

InnateDB Protein

IDBP-537448.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs6

Protein Name

suppressor of cytokine signaling 6

Synonyms

1500012M23Rik; 5830401B18Rik; AI447482; Cis4; Cish4; HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118764

InnateDB Gene

IDBG-163115 (Socs6)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0009968	negative regulation of signal transduction
GO:0010498	proteasomal protein catabolic process
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0050868	negative regulation of T cell activation