Version 5.4
Mus musculus Gene: Socs6
Summary
InnateDB Gene IDBG-163115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Socs6
Gene Name suppressor of cytokine signaling 6
Synonyms 1500012M23Rik; 5830401B18Rik; AI447482; Cis4; Cish4; HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4
Species Mus musculus
Ensembl Gene ENSMUSG00000056153
Encoded Proteins
IDBP-163117
suppressor of cytokine signaling 6
IDBP-535108
suppressor of cytokine signaling 6
IDBP-537448
suppressor of cytokine signaling 6
IDBP-538360
suppressor of cytokine signaling 6
IDBP-537855
suppressor of cytokine signaling 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 14707129
[Homo sapiens] SOCS6 associates with KIT and regulates KIT receptor signalling and leads to MAPK activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170677:
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:88665224-88927481
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000070116 ENSMUSP00000064929
ENSMUST00000155169
ENSMUST00000136173
ENSMUST00000123826 ENSMUSP00000114993
ENSMUST00000125362 ENSMUSP00000118764
ENSMUST00000145120 ENSMUSP00000122237
ENSMUST00000147313 ENSMUSP00000116148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0009968 negative regulation of signal transduction
GO:0010498 proteasomal protein catabolic process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0001772 immunological synapse
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170677
View Gene Order
ENSBTAG00000017412
Not yet available
Pathways
NETPATH
REACTOME
REACT_227425
Regulation of KIT signaling pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt Q9JLY0
TrEMBL D3Z776
UniProt Splice Variant
Entrez Gene 54607
UniGene Mm.462378 Mm.475026 Mm.484349 Mm.91920
RefSeq NM_018821 XM_006526513 XM_006526514
OMIM
CCDS CCDS29389
HPRD
IMGT
MGI ID MGI:1924885
MGI Symbol Socs6
EMBL AC118614 AC122398 AC165161 AF121907 AK019993 AK028665 AK028701 AK031164 AK044946 AK142069 AK156591 BC017597 BC094443 CH466632
GenPept AAF28872 AAH17597 AAH94443 BAB31956 BAC26055 BAC26074 BAC27287 BAC32154 BAE24930 BAE33770 EDL00645 EDL00646
RNA Seq Atlas 54607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca