InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prg4

Summary

InnateDB Protein

IDBP-537463.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prg4

Protein Name

proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)

Synonyms

CACP; DOL54; JCAP; lubricin; MSF; SZP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125551

InnateDB Gene

IDBG-197710 (Prg4)

Protein Structure

UniProt Annotation

Function

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. {ECO:0000269PubMed:15719068}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in cartilage, bone and liver and weakly expressed in heart, brain and muscle. Expressed in the surface chondrocytes and in synovial intimal cells. Isoform B is expressed in bone, small intestine, muscle, testis, heart, liver and lung. Isoform C and isoform D are widely expressed. {ECO:0000269PubMed:11124536, ECO:0000269PubMed:15719068}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0030247	polysaccharide binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0042127	regulation of cell proliferation
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0071425	hematopoietic stem cell proliferation