Version 5.4
Mus musculus Gene: Prg4
Summary
InnateDB Gene IDBG-197710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prg4
Gene Name proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms CACP; DOL54; JCAP; lubricin; MSF; SZP
Species Mus musculus
Ensembl Gene ENSMUSG00000006014
Encoded Proteins
IDBP-197712
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-257148
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-257150
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-537463
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-536122
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-539633
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-536722
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
IDBP-620247
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116690:
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150449412-150466165
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000006171 ENSMUSP00000006171
ENSMUST00000111902 ENSMUSP00000107533
ENSMUST00000111901 ENSMUSP00000107532
ENSMUST00000162367 ENSMUSP00000125551
ENSMUST00000161611 ENSMUSP00000125677
ENSMUST00000161320 ENSMUSP00000124801
ENSMUST00000159035 ENSMUSP00000124410
ENSMUST00000164600 ENSMUSP00000128943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0030247 polysaccharide binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006955 immune response
GO:0018149 peptide cross-linking
GO:0042127 regulation of cell proliferation
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0071425 hematopoietic stem cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116690
View Gene Order
ENSBTAG00000011932
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.329131
RefSeq NM_001110146 NM_021400 XM_006529966
OMIM
CCDS CCDS48391 CCDS48392
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca