InnateDB Protein
|
IDBP-537567.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Bag5
|
Protein Name
|
BCL2-associated athanogene 5
|
Synonyms
|
1600025G07Rik; 4930405J06Rik;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000125183
|
InnateDB Gene
|
IDBG-173485 (Bag5)
|
Protein Structure
|
|
Function |
May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). {ECO:0000250}.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
14 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0031397
|
negative regulation of protein ubiquitination
|
GO:0051444
|
negative regulation of ubiquitin-protein transferase activity
|
GO:0061084
|
negative regulation of protein refolding
|
GO:0070997
|
neuron death
|
GO:0090083
|
regulation of inclusion body assembly
|
|
Cellular Component |
|
PDB ID |
MGI:1917619
|
InterPro |
IPR003103
BAG domain
|
PFAM |
PF02179
|
PRINTS |
|
PIRSF |
|
SMART |
SM00264
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8CI32
|
PhosphoSite |
PhosphoSite-Q8CI32
|
TrEMBL |
E0CYW3
|
UniProt Splice Variant |
|
Entrez Gene |
70369
|
UniGene |
Mm.44239
|
RefSeq |
XP_006516279
|
MGI ID |
|
MGI Symbol |
Bag5
|
OMIM |
|
CCDS |
CCDS26185
|
HPRD |
|
IMGT |
|
EMBL |
AC152065
AK005534
AK160246
BC027827
BC037642
|
GenPept |
AAH27827
AAH37642
BAB24105
BAE35711
|
|
|