Version 5.4
Mus musculus Protein: Mkl1
Summary
InnateDB Protein IDBP-537634.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mkl1
Protein Name MKL (megakaryoblastic leukemia)/myocardin-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000118451
InnateDB Gene IDBG-164431 (Mkl1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051145 smooth muscle cell differentiation
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2384495
InterPro IPR003034 SAP domain
IPR004018 RPEL repeat
PFAM PF02037
PF02755
PRINTS
PIRSF
SMART SM00513
SM00707
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YUG5
UniProt Splice Variant
Entrez Gene 223701
UniGene Mm.439814
RefSeq
MGI ID
MGI Symbol Mkl1
OMIM
CCDS
HPRD
IMGT
EMBL AC102198 AC141880
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca