Version 5.4
Mus musculus Protein: Fgf13
Summary
InnateDB Protein IDBP-537674.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgf13
Protein Name fibroblast growth factor 13
Synonyms Fhf2;
Species Mus musculus
Ensembl Protein ENSMUSP00000114905
InnateDB Gene IDBG-147880 (Fgf13)
Protein Structure
UniProt Annotation
Function Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.Isoform 1 seems not to be involved in neuroblast polarization and migration but regulates axon branching.May regulate voltage-gated sodium channels transport and function.May also play a role in MAPK signaling.
Subcellular Localization Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes.Isoform 1: Nucleus.Isoform 2: Cytoplasm.
Disease Associations
Tissue Specificity Detected in brain, eye and heart. In brain, the different isoforms display different patterns of expression. Expressed in brain and heart (at protein level). Isoform 3 is highly expressed in cardiac myocytes while isoform 1 is the most abundant in brain. {ECO:0000269PubMed:10644718, ECO:0000269PubMed:21817159, ECO:0000269PubMed:9232594}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Protein Structure and Domains
PDB ID MGI:109178
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P70377
TrEMBL B1AU23
UniProt Splice Variant
Entrez Gene 14168
UniGene Mm.7995
RefSeq
MGI ID
MGI Symbol Fgf13
OMIM
CCDS
HPRD
IMGT
EMBL AL669891 AL672247 AL713968
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca