InnateDB Protein
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IDBP-537724.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Acsl3
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Protein Name
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acyl-CoA synthetase long-chain family member 3
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Synonyms
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2610510B12Rik; Acs3; C85929; Facl3; Pro2194;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000121695
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InnateDB Gene
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IDBG-172590 (Acsl3)
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Protein Structure
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Function |
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 has mainly an anabolic role in energy metabolism (By similarity). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921455
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InterPro |
IPR000873
AMP-dependent synthetase/ligase
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PFAM |
PF00501
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CZW4
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PhosphoSite |
PhosphoSite-Q9CZW4
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TrEMBL |
E9PUC2
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UniProt Splice Variant |
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Entrez Gene |
74205
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UniGene |
Mm.401353
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RefSeq |
NP_001028778
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MGI ID |
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MGI Symbol |
Acsl3
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OMIM |
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CCDS |
CCDS15087
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HPRD |
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IMGT |
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EMBL |
AC156613
AK012088
AK161708
BC031529
CH466548
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GenPept |
AAH31529
BAB28022
BAE36543
EDL00440
EDL00441
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