Version 5.4
Mus musculus Protein: Srrm1
Summary
InnateDB Protein IDBP-537931.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srrm1
Protein Name serine/arginine repetitive matrix 1
Synonyms AA407769; POP101; Srm160;
Species Mus musculus
Ensembl Protein ENSMUSP00000125003
InnateDB Gene IDBG-196857 (Srrm1)
Protein Structure
UniProt Annotation
Function Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus matrix {ECO:0000255PROSITE- ProRule:PRU00627}. Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00627}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 116 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 116 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1858303
InterPro IPR002483 PWI domain
PFAM PF01480
PRINTS
PIRSF
SMART SM00311
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q52KI8
PhosphoSite PhosphoSite-Q52KI8
TrEMBL E9PUK6
UniProt Splice Variant
Entrez Gene 51796
UniGene Mm.471009
RefSeq NP_058079
MGI ID
MGI Symbol Srrm1
OMIM
CCDS CCDS38919
HPRD
IMGT
EMBL AF062655 AK008284 AL627078 AL627185 BC094322
GenPept AAC17422 AAH94322 BAB25575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca