Version 5.4
Mus musculus Protein: Lass1
Summary
InnateDB Protein IDBP-537999.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lass1
Protein Name LAG1 homolog, ceramide synthase 1
Synonyms AI385651; Gdf-1; Lass1; to; Uog-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000120598
InnateDB Gene IDBG-487911 (Lass1)
Protein Structure
UniProt Annotation
Function May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. {ECO:0000269PubMed:12105227}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Brain-specific. {ECO:0000269PubMed:15823095}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0050291 sphingosine N-acyltransferase activity
Biological Process
GO:0046513 ceramide biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:2136690
InterPro IPR006634 TRAM/LAG1/CLN8 homology domain
IPR016439 Longevity assurance, LAG1/LAC1
PFAM PF03798
PRINTS
PIRSF PIRSF005225
SMART SM00724
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27545
PhosphoSite PhosphoSite-
TrEMBL A2RT05
UniProt Splice Variant
Entrez Gene 93898
UniGene Mm.481331
RefSeq NP_619588
MGI ID
MGI Symbol Cers1
OMIM
CCDS CCDS52570
HPRD
IMGT
EMBL BC132318 CH466569 M62301
GenPept AAA37675 AAI32319 EDL28811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca