InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lass1

Summary

InnateDB Gene

IDBG-487911.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lass1

Gene Name

LAG1 homolog, ceramide synthase 1

Synonyms

AI385651; Gdf-1; Lass1; to; Uog-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000087408

Encoded Proteins

IDBP-537999

LAG1 homolog, ceramide synthase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The orthologous human protein has been shown to regulate C18-ceramide (N-stearoyl-sphinganine) synthesis. The protein is expressed from a bicistronic mRNA which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2009]
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes the LAG1 homolog, ceramide synthase 1 gene. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:70315775-70331592

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000140239	ENSMUSP00000120598
ENSMUST00000136257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0040007	growth
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle