InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cep57

Summary

InnateDB Protein

IDBP-538070.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cep57

Protein Name

centrosomal protein 57

Synonyms

3110002L15Rik; 4921510P06Rik; 4931428M20Rik; AI467480; mKIAA0092; Tsp57;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119081

InnateDB Gene

IDBG-134181 (Cep57)

Protein Structure

UniProt Annotation

Function

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2. {ECO:0000269PubMed:12717444, ECO:0000269PubMed:18294141}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:12954732, ECO:0000269PubMed:18294141}.

Disease Associations

Tissue Specificity

Ubiquitous (at protein level). Expressed in testis, predominantly in round spermatids. Low expression is detected in other tissues. {ECO:0000269PubMed:12954732, ECO:0000269PubMed:18294141}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017134	fibroblast growth factor binding
GO:0042803	protein homodimerization activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0007286	spermatid development
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034453	microtubule anchoring
GO:0051260	protein homooligomerization