InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirpa

Summary

InnateDB Protein

IDBP-538076.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirpa

Protein Name

signal-regulatory protein alpha

Synonyms

AI835480; Bit; CD172a; P84; Ptpns1; SHP-1; SHPS-1; SIRP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125004

InnateDB Gene

IDBG-206000 (Sirpa)

Protein Structure

UniProt Annotation

Function

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in cerebral cortex, brain, spinal cord, cerebellum and spleen, and at much lower levels in kidney, thymus, heart, lung and liver. Within the cerebellum, highly expressed throughout the molecular layer, and in synaptic glomeruli in the granule cell layer. Detected in neurons of the hippocampus and dentate gyrus, and in olfactory bulb. Not detected in Purkinje cells. Highly expressed in the plexiform layers, optic fiber layer and the outer segments of the photoreceptor layer in the retina. Highly expressed in macrophages. Isoform 3 is detected at very low levels in all tissues tested. {ECO:0000269PubMed:2303162, ECO:0000269PubMed:9348339, ECO:0000269PubMed:9712903, ECO:0000269PubMed:9872987}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0007160	cell-matrix adhesion
GO:0050766	positive regulation of phagocytosis