InnateDB Protein
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IDBP-538085.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cenpa
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Protein Name
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centromere protein A
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Synonyms
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Cenp-A;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122831
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InnateDB Gene
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IDBG-146055 (Cenpa)
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Protein Structure
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Function |
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
68 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88375
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InterPro |
IPR000164
Histone H3
IPR007125
Histone core
IPR009072
Histone-fold
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PFAM |
PF00125
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PRINTS |
PR00622
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PIRSF |
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SMART |
SM00428
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TIGRFAMs |
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Modification |
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SwissProt |
O35216
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PhosphoSite |
PhosphoSite-O35216
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12615
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UniGene |
Mm.460319
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RefSeq |
NP_031707
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MGI ID |
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MGI Symbol |
Cenpa
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OMIM |
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CCDS |
CCDS19162
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HPRD |
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IMGT |
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EMBL |
AF012709
AF012710
AK010718
AK011399
AK053763
AK089033
BC011038
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GenPept |
AAC39957
AAC39958
AAH11038
BAB27140
BAB27591
BAC35512
BAC40710
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