InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cenpa

Summary

InnateDB Gene

IDBG-146055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cenpa

Gene Name

centromere protein A

Synonyms

Cenp-A

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029177

Encoded Proteins

IDBP-146057

centromere protein A

IDBP-532376

centromere protein A

IDBP-538085

centromere protein A

IDBP-535786

centromere protein A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115163:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:30666777-30674827

Strand

Forward strand

Band

Transcripts

ENSMUST00000031073	ENSMUSP00000031073
ENSMUST00000133316	ENSMUSP00000123493
ENSMUST00000144742	ENSMUSP00000122831
ENSMUST00000134846	ENSMUSP00000119363
ENSMUST00000150810
ENSMUST00000149759
ENSMUST00000134372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0006334	nucleosome assembly
GO:0051382	kinetochore assembly
GO:0071459	protein localization to chromosome, centromeric region

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0000786	nucleosome
GO:0000939	condensed chromosome inner kinetochore
GO:0005634	nucleus