InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cnot8

Summary

InnateDB Protein

IDBP-538094.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot8

Protein Name

CCR4-NOT transcription complex, subunit 8

Synonyms

1500015I04Rik; 1810022F04Rik; AA536816; AU015770; AU043059;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116116

InnateDB Gene

IDBG-176044 (Cnot8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004535	poly(A)-specific ribonuclease activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0030014	CCR4-NOT complex

Protein Structure and Domains

PDB ID

MGI:1916375

InterPro

IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain

PFAM

PF04857

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2AFQ7

UniProt Splice Variant

Entrez Gene

69125

UniGene

Mm.399658

RefSeq

MGI ID

MGI Symbol

Cnot8

OMIM

CCDS

HPRD

IMGT

EMBL

AL672182

GenPept