InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpd1l

Summary

InnateDB Protein

IDBP-538234.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpd1l

Protein Name

glycerol-3-phosphate dehydrogenase 1-like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117509

InnateDB Gene

IDBG-203718 (Gpd1l)

Protein Structure

UniProt Annotation

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0017080	sodium channel regulator activity
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0050662	coenzyme binding
GO:0051287	NAD binding

Biological Process

GO:0002027	regulation of heart rate
GO:0005975	carbohydrate metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006734	NADH metabolic process
GO:0010765	positive regulation of sodium ion transport
GO:0019674	NAD metabolic process
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0046168	glycerol-3-phosphate catabolic process
GO:0055114	oxidation-reduction process
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0086005	ventricular cardiac muscle cell action potential
GO:0090038	negative regulation of protein kinase C signaling
GO:2000010	positive regulation of protein localization to cell surface
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009331	glycerol-3-phosphate dehydrogenase complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1289257

InterPro

IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic

PFAM

PF07479
PF01210

PRINTS

PR00077

PIRSF

PIRSF000114

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt