InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAB2

Summary

InnateDB Protein

IDBP-53825.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAB2

Protein Name

stabilin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373539

InnateDB Gene

IDBG-53819 (STAB2)

Protein Structure

UniProt Annotation

Function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. {ECO:0000269PubMed:12077138, ECO:0000269PubMed:12473645, ECO:0000269PubMed:15208308, ECO:0000269PubMed:15572036, ECO:0000269PubMed:17145755, ECO:0000269PubMed:17675564, ECO:0000269PubMed:17962816, ECO:0000269PubMed:18230608, ECO:0000269PubMed:18434317, ECO:0000269PubMed:18573870, ECO:0000269PubMed:19359419}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface.

Disease Associations

Tissue Specificity

Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC- cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line. {ECO:0000269PubMed:11829752, ECO:0000269PubMed:12077138, ECO:0000269PubMed:12473645, ECO:0000269PubMed:12626425, ECO:0000269PubMed:17675564, ECO:0000269PubMed:17962816}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0001525	angiogenesis
GO:0005975	carbohydrate metabolic process
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0010468	regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0042742	defense response to bacterium
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0030666	endocytic vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR000782 FAS1 domain
IPR001881 EGF-like calcium-binding domain
IPR002049 EGF-like, laminin
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR016187 C-type lectin fold

PFAM

PF00193
PF00008
PF02469
PF07645
PF00053

PRINTS

PR01265

PIRSF

SMART

SM00445
SM00181
SM00554
SM00179
SM00180

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt