InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adhfe1

Summary

InnateDB Protein

IDBP-538322.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adhfe1

Protein Name

alcohol dehydrogenase, iron containing, 1

Synonyms

6330565B14Rik; Adh8; AI043035;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116627

InnateDB Gene

IDBG-132385 (Adhfe1)

Protein Structure

UniProt Annotation

Function

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:17559793}.

Disease Associations

Tissue Specificity

Expressed in white and brown adipose tissues, liver, and kidney. Expression is differentiation-dependent during in vitro brown and white adipogenesis. {ECO:0000269PubMed:17559793}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0047988	hydroxyacid-oxoacid transhydrogenase activity

Biological Process

GO:0015993	molecular hydrogen transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1923437

InterPro

IPR001670 Alcohol dehydrogenase, iron-type

PFAM

PF00465

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R0N6

PhosphoSite

PhosphoSite-Q8R0N6

TrEMBL

UniProt Splice Variant

Entrez Gene

76187

UniGene

Mm.406634

RefSeq

NP_780445

MGI ID

MGI Symbol

Adhfe1

OMIM

CCDS

CCDS14812

HPRD

IMGT

EMBL

AK038853 AK050178 BC026584

GenPept

AAH26584 BAC30151 BAC34108