Version 5.4
Mus musculus Gene: Adhfe1
Summary
InnateDB Gene IDBG-132385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adhfe1
Gene Name alcohol dehydrogenase, iron containing, 1
Synonyms 6330565B14Rik; Adh8; AI043035
Species Mus musculus
Ensembl Gene ENSMUSG00000025911
Encoded Proteins
IDBP-714914
IDBP-538322
alcohol dehydrogenase, iron containing, 1
IDBP-715718
IDBP-788211
alcohol dehydrogenase, iron containing, 1
IDBP-788212
alcohol dehydrogenase, iron containing, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147576:
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:9547948-9580673
Strand Forward strand
Band A2
Transcripts
ENSMUST00000027044 ENSMUSP00000137782
ENSMUST00000144177 ENSMUSP00000116627
ENSMUST00000130927 ENSMUSP00000137817
ENSMUST00000186467 ENSMUSP00000140861
ENSMUST00000190654 ENSMUSP00000140592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0047988 hydroxyacid-oxoacid transhydrogenase activity
Biological Process
GO:0015993 molecular hydrogen transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147576
View Gene Order
ENSBTAG00000004476
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_198633
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25367
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28514 Mm.406634
RefSeq NM_175236 XM_006495585 XM_006495586 XM_006495587
OMIM
CCDS CCDS14812
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca