InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srgn

Summary

InnateDB Protein

IDBP-538396.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srgn

Protein Name

serglycin

Synonyms

Prg; Prg1; Sgc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125622

InnateDB Gene

IDBG-157635 (Srgn)

Protein Structure

UniProt Annotation

Function

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269PubMed:15231821, ECO:0000269PubMed:16046402, ECO:0000269PubMed:16807245, ECO:0000269PubMed:17010166, ECO:0000269PubMed:17081126, ECO:0000269PubMed:17147513, ECO:0000269PubMed:17272511}.

Subcellular Localization

Cytoplasmic granule {ECO:0000269PubMed:16046402}. Secreted, extracellular space {ECO:0000269PubMed:16046402}. Golgi apparatus {ECO:0000250}. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T-lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0016485	protein processing
GO:0030502	negative regulation of bone mineralization
GO:0031214	biomineral tissue development
GO:0033364	mast cell secretory granule organization
GO:0033371	T cell secretory granule organization
GO:0033373	maintenance of protease location in mast cell secretory granule
GO:0033382	maintenance of granzyme B location in T cell secretory granule
GO:0050710	negative regulation of cytokine secretion