Version 5.4
Mus musculus Gene: Srgn
Summary
InnateDB Gene IDBG-157635.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srgn
Gene Name serglycin
Synonyms Prg; Prg1; Sgc
Species Mus musculus
Ensembl Gene ENSMUSG00000020077
Encoded Proteins
IDBP-157637
serglycin
IDBP-538396
serglycin
IDBP-537909
serglycin
IDBP-540546
serglycin
IDBP-531635
serglycin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122862:
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:62493833-62527451
Strand Reverse strand
Band B4
Transcripts
ENSMUST00000020271 ENSMUSP00000020271
ENSMUST00000160987 ENSMUSP00000125622
ENSMUST00000162161 ENSMUSP00000125533
ENSMUST00000160643 ENSMUSP00000124365
ENSMUST00000159020 ENSMUSP00000125385
ENSMUST00000162956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0016485 protein processing
GO:0030502 negative regulation of bone mineralization
GO:0031214 biomineral tissue development
GO:0033364 mast cell secretory granule organization
GO:0033371 T cell secretory granule organization
GO:0033373 maintenance of protease location in mast cell secretory granule
GO:0033382 maintenance of granzyme B location in T cell secretory granule
GO:0050710 negative regulation of cytokine secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0042588 zymogen granule
GO:0042629 mast cell granule
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000122862
View Gene Order
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P13609
TrEMBL E0CYA5
UniProt Splice Variant
Entrez Gene 19073
UniGene Mm.467094 Mm.486627 Mm.488040
RefSeq NM_011157 XM_006513375 XM_006513376
OMIM
CCDS CCDS23889
HPRD
IMGT
MGI ID MGI:97756
MGI Symbol Srgn
EMBL AC126428 AK087960 AK151357 AK157945 BC037076 J04549 M27391 M27392 M27393 M33499 M34603 X16133
GenPept AAA39900 AAA39965 AAA39991 AAA40111 AAH37076 BAC40059 BAE30332 BAE34275 CAA34259
RNA Seq Atlas 19073

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca