Version 5.4
Mus musculus Protein: Nos1ap
Summary
InnateDB Protein IDBP-538460.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nos1ap
Protein Name nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms 6330408P19Rik; Capon;
Species Mus musculus
Ensembl Protein ENSMUSP00000125251
InnateDB Gene IDBG-203777 (Nos1ap)
Protein Structure
UniProt Annotation
Function Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1917979
InterPro IPR006020 PTB/PI domain
PFAM PF00640
PF14719
PRINTS
PIRSF
SMART SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D3A8
PhosphoSite PhosphoSite-Q9D3A8
TrEMBL B7ZNH1
UniProt Splice Variant
Entrez Gene 70729
UniGene Mm.459429
RefSeq NP_001103455
MGI ID
MGI Symbol Nos1ap
OMIM
CCDS CCDS48438
HPRD
IMGT
EMBL AC119431 AC123650 AC125017 AC125021 AK018149 AK122290 BC145237
GenPept AAI45238 BAB31095 BAC65572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca