Version 5.4
Mus musculus Gene: Nos1ap
Summary
InnateDB Gene IDBG-203777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nos1ap
Gene Name nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms 6330408P19Rik; Capon
Species Mus musculus
Ensembl Gene ENSMUSG00000038473
Encoded Proteins
IDBP-538460
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-532505
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-535529
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-538929
nitric oxide synthase 1 (neuronal) adaptor protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198929:
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:170298193-170589861
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000161221
ENSMUST00000160456 ENSMUSP00000125251
ENSMUST00000162709
ENSMUST00000162090
ENSMUST00000160466 ENSMUSP00000125687
ENSMUST00000161966 ENSMUSP00000124240
ENSMUST00000161485 ENSMUSP00000124169
ENSMUST00000160816
ENSMUST00000159665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198929
View Gene Order
ENSBTAG00000010158
Not yet available
Cross-References
SwissProt
TrEMBL E9PYK5 Q3TRB6
UniProt Splice Variant
Entrez Gene 70729
UniGene Mm.405454 Mm.409223 Mm.459429
RefSeq NM_001109985 NM_001198955 NM_027528 XM_006497077
OMIM
CCDS CCDS48437 CCDS48438 CCDS56652
HPRD
IMGT
MGI ID MGI:1917979
MGI Symbol Nos1ap
EMBL AC119431 AC123650 AC125017 AC125021 AK138471 AK162919
GenPept BAE23672 BAE37114
RNA Seq Atlas 665574 70729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca